I don't have tons of Webflow experience but I have a lot in Figma. Recently we adopted a massive colour system and UI elements into relume's styleguide. Adapting and slightly changing the grouping of colours or elements wasn't that hard because Relume's system fitted many ways already. However I was really frustrated of Webflow's interface. I mean reorder the the variables not possible and there is no alphabetical option either. 馃槄 Maybe a plugin to solve this? Dunno
Generally "modes" was the only missing part for our project but it's not a dealbreaker. Overall I enjoy to use Relume's starter file and I always redesign the whole thing to match the projects guidelines. So satisfying 馃